 |
|
Effects of Drug Vehicles on Ocular Contact Time
Rufus Hardberger, MD;
Calvin Hanna, PhD;
Charles M. Boyd, MD
Arch Ophthalmol. 1975;93(1):42-45.
Abstract
Radioactive sodium pentechnetate Tc 99m was added to commonly used ophthalmic drug vehicles of saline, 1% methylcellulose, 1.4% polyvinyl alcohol, and a 6:4 mixture of white petrolatum-mineral oil ointment. These drug vehicles containing99mTc were placed on both rabbit and human eyes and the rate of disappearance of the radioactivity determined. The ocular retention of99mTc by the eye was much longer in the nonblinking eye regardless of the vehicle used. The rate of loss of99mTc from the eye was fastest with saline and slowest with the ointment, with methylcellulose and polyvinyl alcohol in between. The longest contact time of the drug vehicle with the eye is afforded by the use of the ointment vehicle and the covering of both eyes.
Author Affiliations
From the departments of ophthalmology, pharmacology, and nuclear medicine, University of Arkansas Medical Center, Little Rock.
Footnotes
Submitted for publication April 30, 1973.
Reprint requests to 4301 W Markham, Little Rock, AR 72201. (Dr. Hanna).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Topically Applied Aminocaproic Acid Concentrates in the Aqueous Humor of the Rabbit in Therapeutic Levels
Allingham et al.
Arch Ophthalmol 1987;105:1421-1423.
ABSTRACT
Ocular Penetration of Topical Chloramphenicol in Humans
Hanna et al.
Arch Ophthalmol 1978;96:1258-1261.
ABSTRACT
Evaluation of Drugs in Ointment for Mydriasis and Cycloplegia
Cable et al.
Arch Ophthalmol 1978;96:84-86.
ABSTRACT
Chloramphenicol Penetration Into Eyes-Reply
George and Hanna
Arch Ophthalmol 1977;95:1650-1650.
ABSTRACT
Decreased Basal Tear Production Associated With General Anesthesia
Krupin et al.
Arch Ophthalmol 1977;95:107-108.
ABSTRACT
|
