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Effects on the Rabbit Corneal Endothelium

William H. Coles, MD, MS

Arch Ophthalmol. 1975;93(1):36-41.

Abstract
The effects of pilocarpine on the healthy rabbit corneal endothelium were studied by in vitro perfusion, photography, and electron microscopy. The toxicity of endothelial cells to pilocarpine was doserelated. Photography showed shrinkage of cells exposed to pilocarpine. The most striking ultrastructure changes were margination of nuclear heterochromatin and cytoplasmic vacuolation.

Author Affiliations
From the Department of Ophthalmology, Medical University of South Carolina, Charleston, SC.

Footnotes
Submitted for publication March 13, 1973.

Reprint requests to Department of Ophthalmology, 80 Barre St, Charleston, SC 29401 (Dr. Coles).

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