This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (29)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Topical vs Subconjunctival Therapy

Jules L. Baum, MD; Michael Barza, MD; Donald Shushan; Louis Weinstein, MD, PhD

Arch Ophthalmol. 1974;92(4):315-317.

Abstract
Topical and subconjunctival therapy with gentamicin sulfate were compared in rabbits following the induction of Pseudomonas and lye corneal ulcers. The concentrations of antibiotic in the cornea were significantly higher with the subconjunctival than with the topical route for Pseudomonas ulcers. In the case of lye ulcers, however, the difference was not statistically significant. Therapeutic levels of gentamicin were maintained in corneal ulcers for at least six hours after a subconjunctivally given injection. In contrast, less than 1µg of the agent was detectable per gram of cornea one hour after cessation of topical application. This study suggests that bacterial ulcers of the cornea might best be managed with a combination of subconjunctival and frequent topical treatment.

Author Affiliations
From the departments of ophthalmology (Dr. Baum) and medicine—infectious disease section (Drs. Barza and Weinstein), New England Medical Center Hospital and Tufts University School of Medicine, Boston.

Footnotes
Submitted for publication April 27, 1973.

Reprint requests to Department of Ophthalmology, New England Medical Center Hospital, 171 Harrison Ave, Boston, MA 02111 (Dr. Baum).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effect of Eye Pigmentation on Transscleral Drug Delivery
Cheruvu et al.
IOVS 2008;49:333-341.
ABSTRACT | FULL TEXT  

Gentamicin, Tobramycin, Amikacin, and Netilmicin Levels in Tears Following Intravenous Administration
Woo et al.
Arch Ophthalmol 1985;103:216-218.
ABSTRACT  

Route of Antibiotic Administration in Bacterial Keratitis
Leibowitz et al.
Arch Ophthalmol 1981;99:1420-1423.
ABSTRACT  

Topical Antibiotic Therapy of Pseudomonas aeruginosa Keratitis
Kupferman and Leibowitz
Arch Ophthalmol 1979;97:1699-1702.
ABSTRACT  

Periocular Injection of Corticosteroids: An Experimental Evaluation of Its Role in the Treatment of Corneal Inflammation
Leibowitz and Kupferman
Arch Ophthalmol 1977;95:311-314.
ABSTRACT