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Toxic Effects and Clearance

Gholam A. Peyman, MD; Donald R. May, MD; Eric S. Ericson, MD; David Apple, MD

Arch Ophthalmol. 1974;92(1):42-47.

Abstract
Gentamicin sulfate was injected into the anterior chamber and vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. No permanent toxic sequelae were produced when 250µg to 8,000µg of gentamicin sulfate were injected into the anterior chamber. Retinal toxicity was noted when 1,000µg of gentamicin sulfate or more were injected into the vitreous body. When 2,000µg to 10,000µg of gentamicin sulfate were injected into the vitreous, cataracts developed. Doses greater than 8,000µg caused keratopathy. In addition, it has been shown that a single intravitreal injection of 500µg of gentamicin sulfate will maintain levels of 4µg/ml or greater inside the vitreous body for 96 hours.

Author Affiliations
Chicago

From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Footnotes
Submitted for publication Dec 29, 1972.

Read in part before the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 27, 1972.

Reprint requests to Department of Ophthalmology, 1855 W Taylor St, Chicago 60612 (Dr. Peyman).

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