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Single Injection Therapy of Experimental Bacterial Endophthalmitis

Donald R. May, MD; Eric S. Ericson, MD; Gholam A. Peyman, MD; Alan J. Axelrod, MD

Arch Ophthalmol. 1974;91(6):487-489.

Abstract
Bacterial endophthalmitis was produced by inoculating the vitreous body of normal rabbit eyes with Pseudomonas aeruginosa. Eyes treated six hours later with a single intravitreal injection of 125µg to 500µg of gentamicin sulfate, in addition to systemically administered gentamicin, uniformly cleared. Control infected eyes treated with systemically administered gentamicin alone were uniformly destroyed. Minute vacuoles that appeared in the lenses of the treated eyes slowly cleared over a period of five weeks, leaving the eyes optically clear. No damage to the retina was observed in treated eyes.

Author Affiliations
Chicago

From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Footnotes
Submitted for publication Dec 29, 1972; accepted Feb 15, 1973.

Presented in part before the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 27, 1972. Also presented as a scientific exhibit at the annual convention of the American Medical Association, San Francisco, June 18-22, 1972.

Reprint requests to Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, 1855 W Taylor St, Chicago 60612 (Dr. May).

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