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I. Clinical Manifestations

Jang O. Oh, MD, PhD; Thomas R. Stevens, MD

Arch Ophthalmol. 1973;90(6):473-476.

Abstract
The clinical manifestations of infection of rabbit eyes with type 2 Herpesvirus hominis (HVH) were compared with the manifestations of a comparable type 1 HVH infection. The principal ocular changes that followed dropping virus of both types onto intact corneas were conjunctivitis, corneal ulceration, pannus, and iritis. Regardless of passage history, all eight strains of type 1 HVH caused superficial keratitis of early onset that healed rapidly without corneal scarring, and the conjunctivitis and iritis were mild or only moderately severe and of short duration. In contrast, all but one of the seven strains of type 2 HVH were much slower to produce lesions, but the lesions were much more severe and of longer duration; an extensive, deep stromal keratitis was regularly produced and eventuated in corneal opacification, total pannus, and scarring.

Author Affiliations
San Francisco

From Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco. Dr. Stevens is now with Southwestern Medical School, University of Texas, Dallas.

Footnotes
Submitted for publication Jan 9,1973.

Read before the national meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 24, 1972.

Reprint requests to Francis I. Proctor Foundation, University of California, San Francisco 94122 (Dr. Oh).

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