This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Hidehiko Matsuda, MD; George K. Smelser, PhD

Arch Ophthalmol. 1973;89(5):396-401.

Abstract
The epithelium and stroma of experimentally alkali-burned corneas were studied by electron microscopy. In the ulcerating corneas, the number of basal epithelial cells increased at the edge of the regenerating epithelium. These corneas had no basement membrane, and many cytoplasmic processes protruded into the stroma. Some of the cytoplasmic processes contained vesicles, and many similar vesicles were found in the superficial stroma around these processes. In the ulcerated stroma, collagen fibers of the most superficial lamellae changed into fine fibrils and were continuous with an exudative mass. The nonulcerated cornea did not show these abnormalities.

These observations suggest that basal cells in the regenerating epithelium secrete some substances into the stroma, which may be responsible for, or related to, ulcer formation in the alkali-burned corneas.

Author Affiliations
New York

From the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York. Dr. Matsuda is now at Hokkaido University, Sapporo, Japan.

Footnotes
Submitted for publication July 28, 1972.

Reprint requests to Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York 10032 (Dr. Smelser).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice
Oshima et al.
Br J Ophthalmol 2006;90:218-222.
ABSTRACT | FULL TEXT  

Thymosin-{beta}4 Modulates Corneal Matrix Metalloproteinase Levels and Polymorphonuclear Cell Infiltration after Alkali Injury
Sosne et al.
IOVS 2005;46:2388-2395.
ABSTRACT | FULL TEXT  

Comparative Studies of Corneal Surface Injury in the Monkey and Rabbit
Hirst et al.
Arch Ophthalmol 1981;99:1066-1073.
ABSTRACT  

Possible Regulatory Mechanisms of the Cornea: I. Epithelial-Stromal Interaction In Vitro
BenEzra and Tanishima
Arch Ophthalmol 1978;96:1891-1896.
ABSTRACT  

Cornea and Sclera
Lemp
Arch Ophthalmol 1976;94:473-490.