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Biological Vitreous SubstitutesInflammatory Response in Normal and Altered Animal Eyes
Ian J. Constable, MB, BS;
David S. Swann, PhD
Arch Ophthalmol. 1972;88(5):544-548.
Abstract
Hyaluronic acid and collagen gel produced a mild inflammatory reaction in normal monkey eyes. Vitreous uptake of iodine I 131 labeled protein, however, remained abnormal for several months after other evidence of inflammation had resolved. Scleral diathermy or cryoapplication increased vitreous isotope uptake five to eight times in the absence of clinical signs of inflammation. The same vitreous substitutes in eyes with markedly abnormal vascular permeability produced a more severe inflammatory reaction at two days. Intensive corticosteroid therapy partly ameliorated this increased reaction.
Author Affiliations
Boston
From the Department of Retina Research, Retina Foundation; Shriners Burns Institute, Massachusetts General Hospital; Harvard Medical School; and Massachusetts Eye and Ear Infirmary, Boston.
Footnotes
Submitted for publication Feb 8, 1972.
Read before the fall meeting of the Association for Research in Vision and Ophthalmology, Miami, Fla, Nov 4, 1971.
Reprint requests to Ophthalmic Library, Retina Foundation, 100 Charles River Plaza, Boston 02114.
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