This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (98)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Isolation From Rabbit Trigeminal Ganglia Between Episodes of Recurrent Ocular Infection

Anthony B. Nesburn, MD; Margery L. Cook, PhD; Jack G. Stevens, DVM, PhD

Arch Ophthalmol. 1972;88(4):412-417.

Abstract
The unscarified eyes of 14 male New Zealand albino rabbits were infected with herpes simplex virus. Most eyes (26 of 28) exhibited recurrent ocular infection. Four to nine months after original infection and between episodes of recurrence, all animals were killed. Conjunctiva, nictitating membrane, lacrimal gland, cornea, iris, preganglionic trigeminal nerve, trigeminal ganglia, and brain tissue containing the trigeminal nerve nucleus were removed from each animal and tested for virus. Herpes simplex virus was recovered only from trigeminal ganglia and only from those portions maintained as organ cultures. Nineteen of 26 ganglia (73%) were positive. These results are consistent with the theory that sensory ganglia act as reservoirs of herpes simplex virus between attacks of overt disease.

Author Affiliations
Los Angeles

From the Infectious Disease Research Unit, Estelle Doheny Eye Foundation Laboratory (Dr. Nesburn), and the Department of Medical Microbiology and Immunology, UCLA (Drs. Cook and Stevens), Los Angeles.

Footnotes
Submitted for publication Feb 4, 1972.

Read in part before the Western Section Meeting of the Association for Research in Vision and Ophthalmology, San Francisco, Aug 27, 1971.

Reprint requests to Estelle Doheny Eye Foundation Laboratory, 272 S Lake St, Los Angeles 90057 (Dr. Nesburn).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Antigens of Herpes Simplex Virus in Whole Corneal Epithelial Sheets From Mice
Shimeld et al.
Arch Ophthalmol 1986;104:1830-1834.
ABSTRACT  

Herpetic Ganglionic Latency: Aciclovir and Vidarabine Therapy
Pavan-Langston et al.
Arch Ophthalmol 1979;97:1508-1510.
ABSTRACT  

Herpetic Eye Disease in Rabbits After Inoculation of Autonomic Ganglia
Mintsioulis et al.
Arch Ophthalmol 1979;97:1515-1517.
ABSTRACT  

Herpetic Whitlow and Keratitis
Eiferman et al.
Arch Ophthalmol 1979;97:1079-1081.
ABSTRACT  

Herpesvirus in Sensory and Autonomic Ganglia After Eye Infection: Absence of Chronic Viral Shedding
Martin et al.
Arch Ophthalmol 1977;95:2053-2056.
ABSTRACT  

Lesions Produced by Human Herpesviruses 1 and 2: Morphologic Features in Rabbit Corneal Epithelium
Hollenberg et al.
Arch Ophthalmol 1976;94:127-134.
ABSTRACT  

Photodynamic Inactivation in Experimental Herpetic Keratitis
Lahav et al.
Arch Ophthalmol 1975;93:207-214.
ABSTRACT  

Photodynamic Inactivation of Herpes Simplex Keratitis
Tara et al.
Arch Ophthalmol 1974;92:51-53.
ABSTRACT  

THE LOS ANGELES DERMATOLOGICAL SOCIETY
Underwood
Arch Dermatol 1974;109:585-587.
ABSTRACT