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Chronic Experimental Allergic Uveitis
Samuel B. Aronson, MD;
Philip R. B. McMaster, MD
Arch Ophthalmol. 1971;86(4):438-442.
Abstract
Chronic experimental allergic uveitis was produced in strain XIII guinea pigs following immunization to homologous uveal antigen in seven sequences at two-week intervals. By the end of the final immunization period (day 103), 13 of 19 animals demonstrated active uveal inflammation; eight of these demonstrated moderate or severe disease. After 14 months, 11 of 13 surviving animals demonstrated clinically active uveitis; a majority demonstrated severe disease. The histologic response was characterized by large sheets of lymphoid elements; in more severe reactions; these were interspersed with foci of polymorphonuclear leukocytes. Immunologic testing revealed reactions to uvea, retinovitreous, and lens extracts. The incidence of positivity of uveal antibody increased with time.
Author Affiliations
San Francisco; Bethesda, Md
From the Eye Research Laboratories and the Department of Ophthalmology, San Francisco General Hospital, University of California School of Medicine, San Francisco (Dr. Aronson), and the Laboratory of Microbial Immunity, National Institutes of Health, Bethesda, Md (Dr. McMaster).
Footnotes
Submitted for publication Jan 13, 1971.
Reprint requests to Department of Ophthalmology, Room 1505, San Francisco General Hospital, 1001 Potrero Ave, San Francisco 94110 (Dr. Aronson).
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ABSTRACT
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