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Treatment With and Evaluation of Carbenicillin and Gentamicin in Combination

George Bohigian, MD; Masao Okumoto, MA; Mario Valenton, MD

Arch Ophthalmol. 1971;86(4):432-437.

Abstract
Although combinations of gentamicin and carbenicillin have acted synergistically on Pseudomonas aeruginosa in vitro, in this study there was no significant evidence that they did so in vivo when given subconjunctivally to rabbits with Pseudomonas keratitis. The clinical and bacteriological effects of gentamicin (10 mg), carbenicillin (114 mg), and polymyxin B sulfate (5 mg) were essentially the same. Combinations of gentamicin and carbenicillin were at least as effective as each antibiotic given alone.

Author Affiliations
San Francisco

From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco. Dr. Bohigian is now with the US Naval Hospital, Camp Lejeune, NC.

Footnotes
Submitted for publication Dec 24, 1970.

Reprint requests to the Francis I. Proctor Foundation, University of California, San Francisco 94122 (Mr. Okumoto).

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