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Roswell R. Pfister, MD; James P. McCulley, MD; Judith Friend, MA; Claes H. Dahlman, MD

Arch Ophthalmol. 1971;86(3):308-313.

Abstract
Collagenase was produced from intact epithelium of nonulcerated rabbit corneas beginning 9 to 15 hours after an alkali burn of the perilimbal sclera. At the same time, glycogen loss from these cells generally paralleled the degree of aqueous glucose depression. Aqueous humor from alkali burned eyes failed to have either facilitative or inhibitory effects on collagenase production in vitro. Persistently low aqueous pH starting 20 minutes after peripheral alkali burning is attributed to increased aqueous lactate.

Author Affiliations
Boston

From the Department of Cornea Research, Retina Foundation, and the Howe Laboratory, Massachusetts Eye and Ear Infirmary, Boston.

Footnotes
Submitted for publication Dec 4, 1970.

Reprint requests to Retina Foundation, 20 Staniford St, Boston 02114 (Dr. Pfister).

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