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Comparison of Intraocular Pressure Effects

Steven M. Podos, MD; Theodore Krupin, MD; Carl Asseff, MD; Bernard Becker, MD

Arch Ophthalmol. 1971;86(3):251-254.

Abstract
Twenty-eight patients highly responsive to topically administered corticosteroids were subjected to various corticosteroid preparations keeping frequency and duration of administration constant. Topical administration of dexamethasone demonstrated a dose-response relationship for concentrations of 0.1%, 0.005%, and 0.001%. One half of the patients showed greater than 5 mm Hg elevations of intraocular pressure after two to six weeks of therapy with the 20 times dilution (0.005%) of dexamethasone. Dexamethasone 0.001%, hydrocortisone 0.5%, and tetrahydrotriamcinolone 0.25% produced less ocular hypertension. Medrysone 1.0% had the smallest effect on intraocular pressure.

Author Affiliations
St. Louis

From the Glaucoma Center, Department of Ophthalmology, and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis.

Footnotes
Submitted for publication Feb 2, 1971.

Read before the Section on Ophthalmology at the 120th annual convention of the American Medical Association, Atlantic City, NJ, June 21, 1971.

Reprint requests to Department of Ophthalmology, Washington University School of Medicine, St. Louis 63110 (Dr. Podos).

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