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Altered Vascular Permeability in Ocular Inflammatory Disease
Samuel B. Aronson, MD;
Mathews B. Fish, MD;
Myron Pollycove, MD;
Margaret A. Coon
Arch Ophthalmol. 1971;85(4):455-466.
Abstract
Three experimental models were utilized to demonstrate the effect of structural alteration following inflammation on ocular vascular permeability and its role in predisposition to inflammatory recurrence. The models studied are (1) the conjunctival immunization model, (2) the intravitreal immunogenic reaction, and (3) penetrating keratoplasty. Each model showed enhanced vascular permeability to human serum albumin labeled with iodine 125 (HSA 125I) during active inflammation and intravascular accumulation of radioactive red blood cells. However, when inflammation had become inactive, vascular permeability was enhanced only for HSA 125I. These findings would indicate a permanent "hole" in the inflamed eye's vascular system which would readily predispose to recurrence of inflammation.
Author Affiliations
San Francisco
From the Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California Medical Center, San Francisco.
Footnotes
Submitted for publication Feb 18, 1970.
Reprint requests to Department of Ophthalmology, Room 1505, San Francisco General Hospital, 1001 Potrero Ave, San Francisco 94110 (Dr. Aronson)
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