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Interrelationship in the Human Eye

Manfred Spitznas, MD; Michael J. Hogan, MD

Arch Ophthalmol. 1970;84(6):810-819.

Abstract
The pigment epithelium has two types of processes: (1) relatively slender, fringe-like villi projecting between the outer segments of the photoreceptors, and (2) broad, rampart-like cytoplasmic sheets encompassing the tips of the outer segments. The latter processes play an important role in the normal cohesion between neuroretina and pigment epithelium. In addition, they are capable of phagocytosing the tips of outer segments by protruding inward from all sides. This leads to the formation of pigment epithelial inclusions termed "phagosomes." The phagosomes disintegrate in the pigment epithelium, which results in a change of their morphology. A classification for these morphologically different pigment epithelial inclusions is proposed.

Author Affiliations
San Francisco

From the Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology, University of California, San Francisco.

Footnotes
Submitted for publication July 2, 1970.

Reprint requests to Department of Ophthalmology, University of California, San Francisco Medical Center, San Francisco 94122 (Dr. Hogan).

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