This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Bruce Golden, MD; Suzanne P. Coppel, PhD

Arch Ophthalmol. 1970;84(6):792-796.

Abstract
Data are presented on the ocular, humor, and tissue concentrations of gentamicin administered by subTenon's and intramuscular routes. The microgram per milliliter concentration of the absorbed antibiotic exceeds the minimum inhibitory concentrations for the majority of organisms commonly infecting the eye at 1 and 24 hours after a subTenon's injection. Intramuscular injections alone do not give detectable antibiotic in the vitreous or lens at any time or in the other ocular tissues, with the exception of conjunctiva, after six hours. While there is not a direct corollary between these experiments done in rabbits and humans, these data indicate that subTenon's injections from 20 to 40 mg should be adequate for most ocular infections if given every 24 hours. Higher levels of ocular tissue concentration may be obtained with concomitant use of gentamicin administered intramuscularly.

Author Affiliations
Iowa City

From the Laboratory of Experimental Ophthalmic Microbiology and Immunology, Department of Ophthalmology, University of Iowa, Iowa City.

Footnotes
Submitted for publication July 27, 1970.

Read before the Association for Research in Ophthalmology, Sarasota, Fla, May 3, 1970.

Reprint requests to Laboratory of Experimental Ophthalmic Microbiology and Immunology, Department of Ophthalmology, University of Iowa, Iowa City 52240 (Dr. Golden).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ocular Penetration of Amikacin Following Intramuscular Injection
Wingfield et al.
Arch Ophthalmol 1983;101:117-120.
ABSTRACT  

Toxicity, Efficacy, and Clearance of Intravitreally Injected Cefazolin
Fisher et al.
Arch Ophthalmol 1982;100:650-652.
ABSTRACT  

Intraocular Penetration of Sisomicin in Rabbits
Faris et al.
Arch Ophthalmol 1980;98:2050-2052.
ABSTRACT  

Ocular Penetration of Topically Applied Gentamicin
Ellerhorst et al.
Arch Ophthalmol 1975;93:371-378.
ABSTRACT  

Concentration of Gentamicin in Experimental Corneal Ulcers: Topical vs Subconjunctival Therapy
Baum et al.
Arch Ophthalmol 1974;92:315-317.
ABSTRACT  

Intraocular Injection of Gentamicin: Toxic Effects and Clearance
Peyman et al.
Arch Ophthalmol 1974;92:42-47.
ABSTRACT  

Intraocular Injection of Gentamicin: Single Injection Therapy of Experimental Bacterial Endophthalmitis
May et al.
Arch Ophthalmol 1974;91:487-489.
ABSTRACT  

Bacterial Endophthalmitis: Treatment With Intraocular Injection of Gentamicin and Dexamethasone
Peyman and Herbst
Arch Ophthalmol 1974;91:416-418.
ABSTRACT  

Cornea and Sclera
Laibson
Arch Ophthalmol 1972;88:553-574.
 

Pseudomonas Corneal Ulcers in Contact Lens Wearers: Epidemiology and Treatment
Golden et al.
Arch Ophthalmol 1971;85:543-547.
ABSTRACT