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B. John Hodgkinson, MD; Helga Kolb, MSc

Arch Ophthalmol. 1970;84(4):509-515.

Abstract
Chloroquine phosphate was administered to pigmented and albino rats via their drinking water for a period of seven months. The rats were divided into high, medium, and low dose groups. Rats of the low dose groups only survived the seven-month period of chloroquine administration and were found to have degenerative changes in their retinae. The chloroquine-induced changes consisted of membranous cytoplasmic bodies (MCBs) appearing in all the neurons of the retina. The pigment epithelium appeared normal.

Author Affiliations
Baltimore

From the Department of Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Baltimore.

Footnotes
Submitted for publication Dec 22, 1969.

Reprint requests to Woods 155, Wilmer Institute, Johns Hopkins Hospital, Baltimore 21205 (Miss Kolb).

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