This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Mercedes Weissenbacher, MD; Norbert Schachter, MD; Miles A. Galin, MD; Samuel Baron, MD

Arch Ophthalmol. 1970;84(4):495-498.

Abstract
Systemic or intraocular administration of the double-stranded RNA inducer of interferon, polyinosinic-polycytidilic acid (In•Cn), produced measurable interferon levels in serum, aqueous, and vitreous. Intraocular levels of interferon are greatest with intravenous administration of In•Cn. The injection of In•Cn into either the anterior chamber or vitreous cavity produces significant intraocular levels of interferon, indicating that the eye is a source for interferon production. Highest levels of vitreous interferon were produced after intravitreal injection of In•Cn.

Author Affiliations
New York; Bethesda, Md

From the Department of Ophthalmology, New York Medical College, New York (Drs. Weissenbacher, Schachter, and Galin), and the US Department of Health, Education, and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md (Dr. Baron).

Footnotes
Submitted for publication Jan 8, 1970.

Reprint requests to Department of Ophthalmology, New York Medical College, Fifth Ave at 106th St, New York 10029 (Dr. Galin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?