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Samuel B. Aronson, MD; Philip R. B. McMaster, MD; Thomas E. Moore, Jr., MD; Margaret A. Coon

Arch Ophthalmol. 1970;84(3):342-349.

Abstract
Evaluation of toxicity in the cyanoacrylate adhesives and their homologs was undertaken in conventional and germ free guinea pigs. Adhesive was applied to the denuded cornea centrally and peripherally and injected intrastromally; all experimental models demonstrated in vivo toxicity. Intrastromal injection and surface application to the central cornea produced the severe inflammatory response in both species.

Author Affiliations
San Francisco

From the Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories at San Francisco General Hospital, University of California, Medical Center, San Francisco.

Footnotes
Submitted for publication Jan 13, 1970.

Reprint requests to Department of Ophthalmology, Room 1505, San Francisco General Hospital, 1001 Potrero Ave, San Francisco 94110. (Dr. Aronson).

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