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I. The Production of Recurrent Immunologic (Auer) Uveitis and Its Relationship to Increased Uveal Vascular Permeability

Charles N. Gamble, MD; Samuel B. Aronson, MD; Frances B. Brescia

Arch Ophthalmol. 1970;84(3):321-330.

Abstract
Recurrent immunologic uveitis has been produced in rabbits by a modification of the Auer reaction. The right eyes of bovine serum albumin (BSA)-sensitized and nonsensitized rabbits were primarily inflamed by the intravitreal injection of Escherichia coli endotoxin. The ensuing intense inflammation of the uveal tract was then allowed to subside until it was minimal or absent. When BSA was then given systemically, acute inflammatory changes recurred only in the previously inflamed right eyes of the sensitized rabbits but not in their left eyes nor in the right and left eyes of control rabbits. Isotope-labeled protein studies revealed that the important underlying mechanism in the pathogenesis of this experimental model of recurrent immunologic uveitis is prolonged increased uveal vascular permeability induced by the primary inflammatory agent.

Author Affiliations
San Francisco

From the Department of Pathology and Laboratory of Ocular Inflammatory Disease, Department of Ophthalmology, University of California School of Medicine, San Francisco.

Footnotes
Submitted for publication Dec 12, 1969.

Reprint requests to Department of Laboratory Medicine, Sutter Memorial Hospital, 52nd and F streets, Sacramento, Calif 95819 (Dr. Gamble).

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