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Animal Trials With a New Glaucoma Drainage Device

Lubomir Krejci, MD; Raymond Harrison, MD; Otto Wichterle, DSc

Arch Ophthalmol. 1970;84(1):76-82.

Abstract
A new drainage device of hydrophilic plastic, hydroxyethyl methacrylate (Hydron), is partially inserted in the anterior chamber. The strip swells and softens on hydration to plug the surgical incision. Parallel "capillary" channels in the strip permit passage of particulate matter and slow drainage of fluid. Implantation of the hydroxyethyl methacrylate capillary strip in 64 rabbit eyes did not result in hypotony but significantly mitigated elevation of intraocular pressure following subconjunctival injection of 15% sodium chloride solution. Control (not operated on) eyes responded to this provocation with marked elevation of pressure. Basal pressure-lowering effect in normal eyes was related to the dimensions of the implants. All implants were retained with filtering blebs and apparently perfect tolerance when observed for one to nine months. For over six months, 50 eyes were followed. Histological examination at all stages showed virtual absence of inflammatory reaction.

Author Affiliations
New York; Prague

From the Eye Bank for Sight Restoration, Inc., and the Glaucoma Service, Manhattan Eye, Ear, and Throat Hospital, New York. Dr. Krejci is a visiting research fellow.

Footnotes
Submitted for publication Oct 8, 1969.

Reprint requests to 140 E 54th St, New York 10022 (Dr. Harrison).

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