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Response to Double-Blind Corticosteroid Therapy

Peter R. Laibson, MD; Shashi Dhiri, MD; Jose Oconer, MD; Guilherme Ortolan, MD

Arch Ophthalmol. 1970;84(1):36-40.

Abstract
Twenty patients with epidemic keratoconjunctivitis without typical subepithelial corneal infiltrates early in the course of their disease were treated in a double-blind regimen with either topical administration of corticosteroid or nonsteroid eye drops for four weeks, four times daily. The corneal infiltrates failed to appear while on steroid therapy in a significant number of patients compared to placebo drops. Subepithelial corneal infiltrates were noted to occur on cessation of administration of corticosteroid drops but once again disappeared if steroids were reinstituted up to one year later. This was also shown in a second double-blind study involving 17 patients nine to twelve months after their initial adenoviral type 8 ocular infection.

Author Affiliations
Philadelphia

From the Cornea Service, Wills Eye Hospital and Research Institute, Philadelphia.

Footnotes
Submitted for publication Dec 8, 1969.

Read before the Spring meeting of the Association for Research in Ophthalmology, Sarasota, Fla, April 22, 1969.

Reprint requests to 1601 Spring Garden St, Philadelphia 19130 (Dr. Laibson).

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