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Measurements of Aqueous Humor Turnover Rates Using a Gamma Probe
Frank J. Macri, PhD;
J. O'Rourke, MD
Arch Ophthalmol. 1970;83(6):741-745.
Abstract
The transcorneal determination of the rate of decay of intracamerally injected iodinated I 125 serum albumin gives an accurate measurement of the rate of aqueous humor formation. The duration of pentobarbital sodium anesthesia had no effect on permeability of the blood-aqueous humor barrier. The blood-aqueous humor barrier, however, did become more permeable to inulin labeled with radioactive carbon (14C) and dextran labeled with radioactive carbon (14C) as a function of elapsed time after the original placements of needles into the anterior chamber. A positive correlation was found between intraocular pressure and the rate of aqueous humor formation in short term experiments. In longer lasting experiments these functions were dissociated.
Author Affiliations
Bethesda, Md; Hartford, Conn
From the Ophthalmology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Md (Dr. Macri), and the Division of Ophthalmology, University of Connecticut Health Center, Hartford, Conn (Dr. O'Rourke).
Footnotes
Submitted for publication Aug 26, 1969.
Reprint requests to the Ophthalmology Branch, National Institute of Neurological Diseases and Stroke, Bldg 10, Room 10N307, Bethesda, Md 20014 (Dr. Macri).
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