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Edward J. Gralla, VMD; Lionel Rubin, VMD

Arch Ophthalmol. 1970;83(6):734-740.

Abstract
Weanling rats given a diet containing 300 mg/100 gm para-chlorophenylalanine develop characteristic anterior and posterior lens changes. Approximately 35% continue to complete cataract development and/or a peculiar retractile lens line. Including phenylalanine 1% or 5% to the same diet protects rats against mature cataracts. However, minor lens changes and the refractile line still appear. The absence of any ocular toxicity in monkeys treated with this agent at 300 mg/kg/ day for one year suggests a specific effect only in rats. Mature rats are more resistant to this cataractogenic effect. These lesions do not regress within one year after drug withdrawal.

Author Affiliations
Groton, Conn; Philadelphia

From the Department of Drug Safety Evaluation, Charles Pfizer and Co., Medical Research Laboratory, Groton, Conn (Dr. Gralla), and the School of Veterinary Medicine, University of Pennsylvania, Philadelphia (Dr. Rubin).

Footnotes
Submitted for publication June 30, 1969.

Reprint requests to the Department of Life Sciences Resources, Yale University Medical School, New Haven, Conn 06510 (Dr. Gralla).

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