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I. The Effect of Antigenic Stimulation

Robert A. Nozik, MD; G. Richard O'Connor, MD

Arch Ophthalmol. 1970;83(6):724-728.

Abstract
Attempts to stimulate recurrent inflammation in the eyes of rabbits with experimentally induced toxoplasmic retinochoroiditis by the injection of Toxoplasma antigens were unsuccessful. Introduction of living Toxoplasma organisms into the suprachoroidal space of eyes with healed, experimentally induced, toxoplasmic retinochoroiditis resulted in a lowgrade inflammatory response. These experiments provide evidence which contradicts the hypothesis that recurrent toxoplasmic retinochoroiditis results from the leakage of Toxoplasma antigens into the tissues of a hypersensitized eye.

Author Affiliations
San Francisco

From the Francis I. Proctor Foundation for Research in Ophthalmology, and Department of Ophthalmology, University of California San Francisco Medical Center.

Footnotes
Submitted for publication Aug 20, 1969.

Reprint requests to Francis I. Proctor Foundation, University of California San Francisco Medical Center, San Francisco 94122 (Dr. Nozik).

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