Ophthalmic Manifestations of Subacute Sclerosing Panencephalitis

doi:10.1001/archopht.1970.00990030426007

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Vol. 83 No. 4, April 1970

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Ophthalmic Manifestations of Subacute Sclerosing Panencephalitis

Richard M. Robb, MD; Gordon V. Watters, MD

Arch Ophthalmol. 1970;83(4):426-435.

Abstract

Case histories of eight patients with subacute sclerosing panencephalitisare presented, with emphasis on ocular manifestations of thedisease. This illness, familiar to European ophthalmologists,is previously unreported in the American ophthalmic literature.Focal chorioretinitis was present in four of the eight patientsand was the most striking ocular manifestation. Nystagmus, corticalblindness, papilledema, and optic atrophy were also presentin some patients. There is evidence that a myxovirus, probablythat of rubeola, is the etiologic agent of this encephalitis;serologic and other tests to identify other etiologies for thechorioretinitis were negative except for possibly coincidentaltoxoplasmic infections in two patients. Further clarificationof the retinal lesions awaits histopathologic study of affectedeyes.

Author Affiliations

Boston

From the departments of ophthalmology (Dr. Robb) and neurology (Dr. Watters), Children's Hospital Medical Center, Harvard University Medical School, Boston.

Footnotes

Submitted for publication June 28, 1969.

Reprint requests to Children's Hospital Medical Center, 300Longwood Ave, Boston 02115 (Dr. Robb).

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