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Phototoxic Corneal and Lens OpacitiesIn Dogs Receiving a Fungicide, 2,6-Dichloro-4-Nitroaniline
Howard N. Bernstein, MD;
Jack Curtis, PhD;
Francis L. Earl, DVM;
Toichiro Kuwabara, MD
Arch Ophthalmol. 1970;83(3):336-348.
Abstract
Corneal and lens opacities were observed in dogs following administration of a fungicide, 2,6-dichloro-4-nitroaniline (DCNA), for longer than six weeks. These changes were irreversible. In the anterior cornea, there were discrete areas of degeneration of the anterior corneal lamella associated with histiocytes containing lipid granules. The predominant effect upon the lens was edema around the anterior Y suture. These corneal and lens abnormalities could only be produced when the animal was exposed to outdoor or natural sunlight illumination. The concept of a phototoxic ocular drug reaction is relatively new in ophthalmology and would appear to deserve increasing attention in the future.
Author Affiliations
Washington, DC; Boston
From the Bureau of Medicine, Office of New Drugs (Dr. Bernstein) and the Bureau of Science, Special Pharmacological Animal Laboratory (Drs. Curtis and Earl), Food and Drug Administration, Department of Health, Education, and Welfare, Washington, DC; and the Howe Laboratory of Ophthalmology, Harvard University Medical School and the Massachusetts Eye and Ear Infirmary, Boston (Dr. Kuwabara).
Footnotes
Submitted for publication Feb 28, 1969.
Read in part before the annual meeting of the Society of Toxicology, Williamsburg, Va, March 5, 1969.
Reprint requests to the Director of Ocular Research, Ocular Research Laboratory, George Hyman Memorial Research Building, Washington Hospital Center, 110 Irving St, Washington, DC (Dr. Bernstein).
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