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Stuart I. Brown, MD; Carol A. Weller, PhD; Shinobu Akiya, MD

Arch Ophthalmol. 1970;83(2):205-208.

Abstract
Intralamellar injections of small quantities of harvested collagenase from the ulcerated tissues of alkali-burned corneas produce full thickness ulcers in intact alkali-burned corneas. This is the final proof that the enzyme is responsible for the ulcers of the alkali-burned cornea. The enzyme is produced by the epithelium and cellular elements of the stroma. A scheme for the pathogenesis of the alkali-burned corneal ulcers is presented and is expanded to implicate the enzyme in many clinical destructive conditions.

Author Affiliations
New York

From the Department of Ophthalmology, Cornea Research Laboratory, New York Hospital-Cornell University Medical Center, New York.

Footnotes
Submitted for publication May 8, 1969.

Reprint requests to the Department of Ophthalmology, Cornea Research Laboratory, New York Hospital-Cornell University Medical Center, 525 E 68th St, New York 10021 (Dr. Brown).

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