 |
|
Collagen Implants in the Vitreous
Michael W. Dunn, MD;
Kurt H. Stenzel, MD;
Albert L. Rubin, MD
Arch Ophthalmol. 1969;82(6):840-844.
Abstract
Proctase-treated collagen solutions and gels were implanted in the anterior chamber and vitreous of 72 rabbit and 27 monkey eyes and their appearance, fate, and effects on surrounding tissue determined. All implants were well-tolerated, although an initial inflammatory response to collagen implants in monkeys exceeded that seen in controls. Ultraviolet irradiation was used to produce collagen gels and to prevent in vivo aggregation of collagen solutions. These implants retained their gel-like structure in vivo and were absorbed from rabbit anterior chambers in two weeks and from monkey vitreous in two months. All implants were totally absorbed without damage to the eyes.
Author Affiliations
New York, and Teruo Miyata, Tokyo
From the Department of Ophthalmology (Dr. Dunn), and the Rogosin Laboratories, departments of surgery and biochemistry, New York Hospital-Cornell Medical Center, New York (Drs. Stenzel and Rubin); and the Collagen Research Laboratory, Japan Leather Company, Ltd., Tokyo (Mr. Miyata).
Footnotes
Submitted for publication April 6, 1969.
Reprint requests to 525 E 68th St, New York 10021 (Dr. Dunn).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Collagen Vitreous Substitute: II. Preliminary Clinical Trials
Pruett et al.
Arch Ophthalmol 1974;91:29-32.
ABSTRACT
Collagen Vitreous Substitute: I. Experimental Study
Pruett et al.
Arch Ophthalmol 1972;88:540-543.
ABSTRACT
Biological Vitreous Substitutes: Inflammatory Response in Normal and Altered Animal Eyes
Constable and Swann
Arch Ophthalmol 1972;88:544-548.
ABSTRACT
The Lens and Vitreous
Freeman
Arch Ophthalmol 1970;84:675-689.
|
