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Wallace S. Foulds, MD, ChM, FRCS; Ian A. Chisholm, MB, ChB, FRCS; Jean Bronte Stewart, MB, ChB; Thomas M. Wilson, MB, ChB

Arch Ophthalmol. 1969;82(4):427-432.

Abstract
The high incidence of pernicious anemia (PA) among patients presenting with tobacco amblyopia is noted. Four patients with PA, two of whom presented initially with visual loss indistinguishable from tobacco amblyopia, and two of whom developed similar symptoms while on treatment with cyanocobalamin are described. In all four cases, the hemopoietic abnormality was restored to normal on treatment with cyanocobalamin, but visual improvement did not occur until treatment was changed to hydroxocobalamin. The significance of these findings is discussed.

Author Affiliations
Glasgow, Scotland

From the Tennent Institute of Ophthalmology, University of Glasgow, Glasgow, Scotland.

Footnotes
Submitted for publication April 14, 1969.

Reprint requests to 38 Church St, Glasgow, W. 1, Scotland (Dr. Foulds).

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