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Preliminary Studies With Collagenase Inhibitors

Stuart I. Brown, MD; Shinobu Akiya, MD; Carol A. Weller, PhD

Arch Ophthalmol. 1969;82(1):95-97.

Abstract
The corneal ulcers and perforations which inevitably occur with severe alkali burns have been prevented in six of eight eyes by the use of collagenase inhibitors. This indicates that collagenase is the cause of the ulcers and suggests an effective treatment for alkali burns and other ulcered states of the cornea where collagenase has been isolated.

Author Affiliations
New York

From the Cornea Research Laboratory, Department of Ophthalmology, New York Hospital-Cornell University Medical Center, New York.

Footnotes
Submitted for publication Dec 23, 1968.

Reprint requests to 525 E 68th St, New York 10021 (Dr. Brown).

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