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Stuart I. Brown, MD; Carol A. Weller, PhD; Herbert E. Wassermann, MD

Arch Ophthalmol. 1969;81(3):370-373.

Abstract
Collagenolytic activity of alkali-burned corneas of rabbits was investigated using a tissue-culture assay technique. The technique was standardized, and in every instance, tissues from the immediate vicinity of the ulcers or perforations showed substantial collagenase production, while generally, tissues more than 2 mm away from the lesions were free of enzyme activity.

Author Affiliations
New York

From the Cornea Research Laboratory, Department of Ophthalmology, New York Hospital-Cornell University Medical School, New York.

Footnotes
Submitted for publication Oct 4, 1968.

Reprint requests to 525 E 68th St, New York 10021 (Dr. Brown).

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