 |
|
Pathogenesis of the Optic Nerve Lesion in Vitamin A-Deficient Calves
K. C. Hayes, DVM, PhD;
S. W. Nielsen, DVM, PhD;
H. D. Eaton, PhD
Arch Ophthalmol. 1968;80(6):777-787.
Abstract
The optic nerves and bony canals from 36 male Holstein calves (23 vitamin A-deficient and 13 adequate) and four 2-year-old heifers (two deficient and two adequate) from five vitamin A experiments were examined. Severe constriction of the optic nerve, which resulted in demyelinization and malacia, was encountered in 14 of the deficient calves, whereas no changes were seen in the older deficient heifers. It is concluded that in the vitamin A deficient growing calf with markedly increased cerebrospinal fluid pressure, altered bone growth, and thickening of the dura mater occur. This is accompanied or followed by vascular occlusion and ischemic necrosis of the nerve as it passes through the optic canal.
Author Affiliations
Storrs, Conn
From the Institute of Nutrition and Food Science, University of Connecticut, Storrs.
Footnotes
Submitted for publication July 3, 1968.
Read in part before the meeting of the International Academy of Pathology, Washington, DC, March 13, 1967.
Reprint requests to Department of Nutrition, Harvard School of Public Health, Boston 02115 (Dr. Hayes).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Anophthalmia and Retinal Degeneration Associated with Stenosis of the Optic Foramen in Fischer 344 Rats
Shibuya et al.
Veterinary Pathology 2000;37:264-267.
ABSTRACT
| FULL TEXT
Status Spongiosis, Optic Neuropathy, and Retinal Degeneration in Helichrysum argyrosphaerum Poisoning in Sheep and a Goat
Lugt et al.
Veterinary Pathology 1996;33:495-502.
ABSTRACT
Bulging Fontanelle as Presenting Sign in Cystic Fibrosis: Vitamin A Metabolism and Effect on Cerebrospinal Fluid Pressure
Abernathy
Arch Pediatr Adolesc Med 1976;130:1360-1362.
ABSTRACT
The Retina and Optic Nerve
L'Esperance
Arch Ophthalmol 1970;83:771-794.
Neuro-ophthalmology
Knox
Arch Ophthalmol 1970;83:103-127.
Pharmacology and Toxicology of Ophthalmic Drugs
Macri
Arch Ophthalmol 1969;82:707-719.
|
