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Harvey H. Slansky, MD; Melvin I. Freeman, MD; Motokazu Itoi, MD

Arch Ophthalmol. 1968;80(4):496-498.

Abstract
Collagenolytic activity was found in bovine corneal epithelium using a synthetic substrate. Increased levels were found after physical disruption of the epithelial cells. This activity was inhibited by disodium ethylene diamine tetraacetate. The release of a collagenolytic enzyme from traumatized epithelial cells may be of clinical importance in the pathogenesis of corneal stromal ulcerations.

Author Affiliations
Boston

From the Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation, Boston.

Footnotes
Submitted for publication March 8, 1968.

Reprint requests to Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation, 20 Staniford St, Boston 02114 (Dr. Slansky).

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