 |
|
Effect of Pilocarpine in Counteracting Mydriasis
Lorene M. Anastasi, MD;
Kenneth N. Ogle, PhD;
Thomas P. Kearns, MD
Arch Ophthalmol. 1968;79(6):710-715.
Abstract
The effectiveness of 1% pilocarpine in counteracting the mydriatic effect of phenylephrine hydrochloride (Neo-Synephrine Hydrochloride), hydroxyamphetamine hydrobromide (Paredrine), tropicamide (Mydriacyl), and homatropine hydrobromide in the concentrations ordinarily used in clinical ophthalmology was studied in 15 subjects. Pupillary diameters were measured with the infrared electronic pupillograph. It was found that the mydriatic effects of the sympathomimetic drugs (phenylephrine and hydroxyamphetamine) are rapidly counteracted by pilocarpine, usually in much less than 30 minutes. However, after mydriasis with parasympatholytic drugs (tropicamide and homatropine), pilocarpine produced little effective miosis and the pupil remained dilated or semidilated for a prolonged period.
Author Affiliations
Rochester, Minn
From the sections of biophysics (Dr. Ogle) and ophthalmology (Dr. Kearns), Mayo Clinic and Foundation, and the Mayo Graduate School of Medicine (Dr. Anastasi), Rochester.
Dr. Ogle died Feb 22, 1968.
Footnotes
Submitted for publication Nov 10, 1967.
Reprint requests to Mayo Clinic, 200 First St SW, Rochester, Minn 55901.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A Guide to the Isolated Dilated Pupil
Lee et al.
Arch Fam Med 1997;6:385-388.
ABSTRACT
Counteracting the Effects of Mydriatics: Does It Benefit the Patient?
Nelson and Orton
Arch Ophthalmol 1987;105:486-489.
ABSTRACT
The Fixed Dilated Pupil: Sudden Iridoplegia or Mydriatic Drops? A Simple Diagnostic Test
Thompson et al.
Arch Ophthalmol 1971;86:21-27.
ABSTRACT
Pharmacology and Toxicology of Ophthalmic Drugs
Macri
Arch Ophthalmol 1969;82:707-719.
|
