 |
|
Vasculo-occlusive Retinopathy in Experimental Allergic Encephalomyelitis
L. von Sallmann, MD;
R. E. Myers, MD, PhD;
E. M. Lerner II, MD;
S. H. Stone, DSc
Arch Ophthalmol. 1967;78(2):112-120.
Abstract
Experimental allergic encephalomyelitis was produced in rhesus monkeys of various ages by injection of guinea pig spinal cord antigen with complete Freund's adjuvant. The eye complications were studied clinically in 24 animals and histologically in 21. In addition to perivascular granulomatous lesions in the optic nerve which have been repeatedly described, signs of vasculoocclusive retinopathy were observed in about 70% of the monkeys. The earliest histologic changes in the retina included obstruction of small vessels by fibrin or fibrinoid accompanied by massive hemorrhages. The retinal damage was seen in all age groups. Mild uveitic reactions were noted frequently. The development of vascular pathology in the retina is a new finding in this autoimmune disease.
Author Affiliations
Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, US Department of Health, Education, and Welfare, Bethesda; the Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, San Juan, Puerto Rico (Dr. Myers); and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda (Drs. Stone and Lerner).
Footnotes
Submitted for publication Dec 12, 1966.
Read before the Inaugural Scientific Program of the Jules Stein Eye Institute, University of California, Los Angeles, Nov 4, 1966.
Reprint requests to the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, Bldg 10, Room 10N307, Bethesda, Md 20014 (Dr. von Sallmann).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Retinal and Uveal Inflammation in Monkeys Following Inoculation With Homologous Retinal Antigen
von Sallmann et al.
Arch Ophthalmol 1969;81:374-382.
ABSTRACT
Autoimmune Chorioretinitis in Rhesus Monkeys
Lerner et al.
Science 1968;162:561-562.
ABSTRACT
Retina and Optic Nerve
Campbell
Arch Ophthalmol 1968;79:789-802.
The Uvea
Aronson
Arch Ophthalmol 1968;79:490-501.
|
