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L. von Sallmann, MD; R. E. Myers, MD, PhD; E. M. Lerner II, MD; S. H. Stone, DSc

Arch Ophthalmol. 1967;78(2):112-120.

Abstract
Experimental allergic encephalomyelitis was produced in rhesus monkeys of various ages by injection of guinea pig spinal cord antigen with complete Freund's adjuvant. The eye complications were studied clinically in 24 animals and histologically in 21. In addition to perivascular granulomatous lesions in the optic nerve which have been repeatedly described, signs of vasculoocclusive retinopathy were observed in about 70% of the monkeys. The earliest histologic changes in the retina included obstruction of small vessels by fibrin or fibrinoid accompanied by massive hemorrhages. The retinal damage was seen in all age groups. Mild uveitic reactions were noted frequently. The development of vascular pathology in the retina is a new finding in this autoimmune disease.

Author Affiliations
Bethesda, Md

From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, US Department of Health, Education, and Welfare, Bethesda; the Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, San Juan, Puerto Rico (Dr. Myers); and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda (Drs. Stone and Lerner).

Footnotes
Submitted for publication Dec 12, 1966.

Read before the Inaugural Scientific Program of the Jules Stein Eye Institute, University of California, Los Angeles, Nov 4, 1966.

Reprint requests to the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, Bldg 10, Room 10N307, Bethesda, Md 20014 (Dr. von Sallmann).

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