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Diagnosis and Grading of Papilledema in Patients With Raised Intracranial Pressure Using Optical Coherence Tomography vs Clinical Expert Assessment Using a Clinical Staging Scale
Colin J. Scott, MD;
Randy H. Kardon, MD, PhD;
Andrew G. Lee, MD;
Lars Frisén, MD, PhD;
Michael Wall, MD
Arch Ophthalmol. 2010;128(6):705-711.
Objectives To compare and contrast 2 methods of quantitating papilledema, namely, optical coherence tomography (OCT) and Modified Frisén Scale (MFS).
Methods Digital optic disc photographs and OCT fast retinal nerve fiber layer (RNFL) thickness, fast RNFL map, total retinal thickness, and fast disc images were obtained in 36 patients with papilledema. Digital optic disc photographs were randomized and graded by 4 masked expert reviewers using the MFS. We performed Spearman rank correlations of OCT RNFL thickness, OCT total retinal thickness, and MFS grade from photographs.
Results OCT RNFL thickness and MFS grade from photographs correlated well (R = 0.85). OCT total retinal thickness and MFS grade from photographs had a similar correlation of 0.87. Comparing OCT RNFL thickness with OCT total retinal thickness, a slope of 1.64 suggests a greater degree of papilledema thickness change when using the latter.
Conclusions For lower-grade abnormalities, OCT compares favorably with clinical staging of optic nerve photographs. With higher grades, OCT RNFL thickness processing algorithms often fail, with OCT total retinal thickness performing more favorably.
Author Affiliations: Department of Ophthalmology and Visual Sciences, Carver School of Medicine, University of Iowa, and Veterans Affairs Hospital, Iowa City (Drs Scott, Kardon, Lee, and Wall); and Institute of Neuroscience and Physiology, Department of Clinical Neurosciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (Dr Frisén). Dr Lee is now with the Department of Ophthalmology, The Methodist Hospital and the Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College New York, New York.
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