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Report of 200 Cases

Flora Levin, MD; Monica Khalil, MD; Steven A. McCormick, MD; David Della Rocca, MD; Elizabeth Maher, MD; Robert C. Della Rocca, MD

Arch Ophthalmol. 2009;127(8):1011-1015.

Objective  To report our experience with 200 cases of basal cell carcinoma (BCC) in 192 patients treated with an enhanced frozen-section control (FSC) technique using stereoscopic microdissection of surgical margins.

Methods  Retrospective series of 192 patients with 200 lesions diagnosed as BCC of the periocular region. All were excised en bloc with 1-mm margins beyond the clinically apparent tumor and examined using an enhanced FSC technique with stereoscopic microdissection of the surgical margins.

Results  Of 200 malignant BCCs, 93.0% represented primary tumors. The overall recurrence rate was 1.0%, with a mean follow-up of 4 years. In patients with primary lesions, the overall recurrence rate was 1.1%, with a mean follow-up of 3.9 years. There were no recurrences in the secondary tumor group after a mean follow-up of 4.8 years. Of the 200 lesions, 66.0% lesions required a single en bloc resection to achieve tumor-free margins.

Conclusions  An enhanced FSC technique using stereoscopic microdissection of the surgical margins permits greater conservation of healthy tissue and yields cure rates comparable to those of the standard FSC technique and Mohs micrographic surgery. We believe that this enhanced FSC technique is a highly effective method for resection of periocular BCC.

Author Affiliations: Edward S. Harkness Eye Institute, Columbia University Medical Center (Dr Levin), Department of Pathology and Laboratory Medicine (Dr McCormick) and Oculoplastic and Orbital Surgery Service (Drs D. Della Rocca, Maher, and R. C. Della Rocca), The New York Eye and Ear Infirmary, and Department of Ophthalmology, St Luke’s Roosevelt Hospital Center (Drs D. Della Rocca and R. C. Della Rocca), New York, New York; and Summit Medical Group, Berkeley Heights, New Jersey (Dr Khalil). Dr Levin is now with the Departments of Ophthalmology at the New York Eye and Ear Infirmary and St Luke’s Roosevelt Hospital Center.

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