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Chatarina Löfqvist, PhD; Ingrid Hansen-Pupp, MD, PhD; Eva Andersson, PhD; Kristina Holm, MD; Lois E. H. Smith, MD, PhD; David Ley, MD, PhD; Ann Hellström, MD, PhD

Arch Ophthalmol. 2009;127(5):622-627.

Objective  To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP).

Methods  Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered.

Results  The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated.

Conclusion  The WINROP algorithm may be a useful tool for modification of ROP screening.

Author Affiliations: Department of Ophthalmology, Institute of Neuroscience and Physiology (Drs Löfqvist and Hellström) and Statistical Research Unit and Department of Occupational and Environmental Medicine (Dr Andersson), Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; Division of Pediatrics, Department of Clinical Sciences, Lund University (Drs Hansen-Pupp and Ley) and Department of Ophthalmology, Lund University Hospital (Dr Holm), Lund, Sweden; and Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Smith).

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