• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Macular Disorders  • Retinal/ Chorioretinal Disorders  • Ocular Imaging  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

SCORE Study Report 4

Amitha Domalpally, MD; Barbara A. Blodi, MD; Ingrid U. Scott, MD, MPH; Michael S. Ip, MD; Neal L. Oden, PhD; Andreas K. Lauer, MD; Paul C. VanVeldhuisen, PhD; for the SCORE Study Investigator Group

Arch Ophthalmol. 2009;127(11):1461-1467.

Objective  To describe grading procedures for optical coherence tomographic (OCT) images of participants in the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study.

Methods  Optical coherence tomograms were taken at clinical sites with the Stratus OCT using fast macular and crosshair scan protocols. Paper prints of images were evaluated at a central reading center. Quality evaluation identified the accuracy of OCT-measured retinal thickness data and was categorized as good, fair, borderline, or ungradable. Manual measurement of center point thickness was performed on borderline images. Morphological evaluation identified cystoid spaces, subretinal fluid, and vitreoretinal interface abnormalities. Reproducibility of grading was assessed through formal quality control exercises.

Results  A randomly selected set of 106 images was identified for quality control. The first 2 annual regrades showed 91% and 89% intergrader agreement for OCT quality. Intraclass correlation for manually measured center point thickness was 0.99 per year. For morphological variables, intergrader agreement for cystoid spaces was 83% and 76%. Reproducibility for subretinal fluid and vitreoretinal interface abnormalities could not be interpreted owing to their limited presence in the sample.

Conclusion  Optical coherence tomogram evaluation procedures used in the SCORE Study are reproducible and can be used for multicenter longitudinal studies of retinal vein occlusion.

Author Affiliations: University of Wisconsin, Madison (Drs Domalpally, Blodi, and Ip); Departments of Ophthalmology and Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania (Dr Scott); The EMMES Corporation, Rockville, Maryland (Drs Oden and VanVeldhuisen); and Casey Eye Institute, Oregon Health & Science University, Portland, Oregon (Dr Lauer).
Group Information: A list of the Standard Care vs Corticosteroid for Retinal Vein Occlusion Study Investigators was published in Arch Ophthalmol. 2009;127(9): 1112-1113.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study System for Evaluation of Stereoscopic Color Fundus Photographs and Fluorescein Angiograms: SCORE Study Report 9
Blodi et al.
Arch Ophthalmol 2010;128:1140-1145.
ABSTRACT | FULL TEXT