 |
|
Acute Zonal Occult Outer Retinopathy in Patients With Multiple Evanescent White Dot Syndrome
Howard F. Fine, MD, MHSc;
Richard F. Spaide, MD;
Edwin H. Ryan Jr, MD;
Yoko Matsumoto, MD;
Lawrence A. Yannuzzi, MD
Arch Ophthalmol. 2009;127(1):66-70.
Objective To describe cases of acute zonal occult outer retinopathy (AZOOR) in patients previously diagnosed as having multiple evanescent white dot syndrome (MEWDS).
Methods In a retrospective case series, we studied fundus photographs, fundus autofluorescence images, optical coherence tomographic scans, fluorescein and indocyanine green angiograms, visual fields, and results of electroretinography.
Results Three patients diagnosed as having MEWDS developed clinical, angiographic, autofluorescence, visual field, and/or electrophysiologic evidence of AZOOR. Spectral domain optical coherence tomographic findings disclosed attenuation of the photoreceptor inner segment–outer segment junction in areas of AZOOR involvement. In 1 patient, hyperautofluorescence on fundus autofluorescence images during the MEWDS episode coincided with the area of involvement of AZOOR.
Conclusions Development of AZOOR may occur in patients with MEWDS, suggesting that the conditions may share a common genetic susceptibility and/or pathogenetic factor. Although the typical visual prognosis after MEWDS is excellent, subsequent diagnosis of AZOOR may portend a worse outcome.
Author Affiliations: Vitreous, Retina, Macula Consultants of New York, LuEsther T. Mertz Retina Research Laboratory, Manhattan Eye, Ear, and Throat Hospital, New York, New York (Drs Fine, Spaide, Matsumoto, and Yannuzzi); Gerstner Clinical Research Center, Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Medical Center, New York (Dr Fine); and Department of Ophthalmology, University of Minnesota, and Vitreoretinal Surgery PA, Minneapolis (Dr Ryan).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
