 |
|
The Relationship of Dietary  -3 Long-Chain Polyunsaturated Fatty Acid Intake With Incident Age-Related Macular DegenerationAREDS Report No. 23
John Paul SanGiovanni, ScD;
Emily Y. Chew, MD;
Elvira Agrón, MA;
Traci E. Clemons, PhD;
Frederick L. Ferris III, MD;
Gary Gensler, MS;
Anne S. Lindblad, PhD;
Roy C. Milton, PhD;
Johanna M. Seddon, MD;
Ronald Klein, MD;
Robert D. Sperduto, MD; for the Age-Related Eye Disease Study Research Group
Arch Ophthalmol. 2008;126(9):1274-1279.
Objective To examine the association of dietary  -3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA).
Methods Multicenter clinic-based prospective cohort study from a clinical trial including Age-Related Eye Disease Study (AREDS) participants with bilateral drusen at enrollment. Main outcome measures were incident neovascular AMD and CGA, ascertained from annual stereoscopic color fundus photographs (median follow-up, 6.3 years). We estimated nutrient and food intake from a validated food frequency questionnaire (FFQ) at baseline, with intake of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), c ombined EPA and DHA, and fish as primary exposures.
Results After controlling for known covariates, we observed a reduced likelihood of progression from bilateral drusen to CGA among people who reported the highest levels of EPA (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.23-0.87) and EPA+DHA (OR, 0.45; 95% CI, 0.23-0.90) consumption. Levels of DHA were associated with CGA in age-, sex-, and calorie-adjusted models (OR, 0.51; 95% CI, 0.26-1.00); however, this statistical relationship did not persist in multivariable models.
Conclusions Dietary lipid intake is a modifiable factor that may influence the likelihood of developing sight-threatening forms of AMD. Our findings suggest that dietary -3 long-chain polyunsaturated fatty acid intake is associated with a decreased risk of progression from bilateral drusen to CGA.
Author Affiliations: National Eye Institute, Bethesda, Maryland (Drs SanGiovanni, Chew, Ferris, and Sperduto and Ms Agrón); The EMMES Corporation, Rockville, Maryland (Drs Clemons, Lindblad, and Milton and Mr Gensler); New England Eye Center, Tufts-New England Medical Center, Boston, Massachusetts (Dr Seddon); and Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison (Dr Klein).
Group Information: A list of the Age-Related Eye Disease Study Research Group members was published in Arch Ophthalmol. 2004;122(5):716-726.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
{omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study
SanGiovanni et al.
Am. J. Clin. Nutr. 2009;90:1601-1607.
ABSTRACT
| FULL TEXT
Association Between Dietary Fat Intake and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): An Ancillary Study of the Women's Health Initiative
Parekh et al.
Arch Ophthalmol 2009;127:1483-1493.
ABSTRACT
| FULL TEXT
Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?
Chiu et al.
Br J Ophthalmol 2009;93:1241-1246.
ABSTRACT
| FULL TEXT
{omega}-3 Long-Chain Polyunsaturated Fatty Acid Intake Inversely Associated With 12-Year Progression to Advanced Age-Related Macular Degeneration
SanGiovanni et al.
Arch Ophthalmol 2009;127:110-112.
FULL TEXT
|
