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Sanjay Asrani, MD; Marinko Sarunic, PhD; Cecilia Santiago, MD; Joseph Izatt, PhD

Arch Ophthalmol. 2008;126(6):765-771.

Objective  To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities.

Methods  A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study.

Results  Schlemm’s canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures. Volumetric imaging was possible and Schlemm’s canal was visualized along part of its circumference.

Conclusion  Anterior segment Fourier-domain optical coherence tomography permits detailed noncontact imaging of the angle and its structures, providing a tool to improve our understanding of the pathogenesis of narrow-angle glaucoma.

Author Affiliations: Duke University Eye Center (Drs Asrani and Santiago) and Department of Biomedical Engineering (Drs Sarunic and Izatt), Duke University, Durham, North Carolina.