This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (1)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neurology  • Neuro-ophthalmology  • Ophthalmological Disorders, Other  • Articles for Residents  • Immunology  • Immunologic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Regina Maria Papais-Alvarenga, MD, MSc, PhD; Sandro Carvalho Carellos, MD, MSc; Marcos Papais Alvarenga, MD; Clarice Holander, MD; Roberly Pinto Bichara, MD, MSc; Luiz Claudio Santos Thuler, MD, MSc, PhD

Arch Ophthalmol. 2008;126(1):12-16.

Objective  To describe the clinical characteristics, course, and prognosis of optic neuritis in recurrent neuromyelitis optica.

Methods  We analyzed 60 patients diagnosed using 1999 Mayo Clinic criteria who were seen between 1985 and 2004 at Hospital da Lagoa (Rio de Janeiro, Brazil).

Results  Optic neuritis was the initial feature in 53.3% of patients, most with unilateral disease. Recurrent optic neuritis before myelitis occurred in 18.3%. The visual impairment was severe at nadir of the visual index event in 78.3%, with a high remission rate. In the median disease duration of 8 years (range, 0.5-30 years), 380 relapses (118 optic neuritis, 223 myelitis, 39 optic neuritis and myelitis) occurred. At the last follow-up, 53.3% of patients had bilateral visual impairment and 63.3% were blind in at least 1 eye. A high mortality rate (23.3%) was due to cervical myelitis. Mortality rates were significantly higher among Afro Brazilian patients (58.3%).

Conclusions  Optic neuritis in patients with recurrent neuromyelitis optica has a severe and acute onset, with predominantly unilateral lesions followed by improvement of clinical symptoms. In the long-term, the disease leads to severe bilateral visual impairment. Mortality rates are higher among patients of Afro Brazilian descent.

Author Affiliations: Neurology Service (Dr R. M. Papais-Alvarenga) and Ophthalmology Service (Drs Holander and Bichara), Hospital da Lagoa, Postgraduation Program (Master of Science in Neurology), Universidade Federal do Estado do Rio de Janeiro (UNIRIO) (Drs R. M. Papais-Alvarenga, Carellos, M. P. Alvarenga, and Thuler), and Instituto Nacional de Câncer (INCA) (Dr Thuler), Rio de Janeiro, Brazil.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLE

Is Neuromyelitis Optica Eyeing a Distinct Path From Multiple Sclerosis?
Christopher C. Glisson and Steven L. Galetta
Arch Ophthalmol. 2008;126(1):128-129.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neuromyelitis optica in Brazil: a study on clinical and prognostic factors
Bichuetti et al.
Mult Scler 2009;15:613-619.
ABSTRACT  

Optic neuritis and risk of MS: Differential diagnosis and management
OSBORNE and VOLPE
Cleveland Clinic Journal of Medicine 2009;76:181-190.
ABSTRACT | FULL TEXT  

Is Neuromyelitis Optica Eyeing a Distinct Path From Multiple Sclerosis?
Glisson and Galetta
Arch Ophthalmol 2008;126:128-129.
FULL TEXT