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High-Frequency Ultrasound Characteristics of 24 Iris and Iridociliary MelanomasBefore and After Plaque Brachytherapy
Paul T. Finger, MD;
Shantan Reddy, MD;
Kimberly Chin, OD
Arch Ophthalmol. 2007;125(8):1051-1058.
Objective To evaluate size, characteristics, and regression of iris and iridociliary melanomas on high-frequency ultrasound images before and after plaque brachytherapy.
Methods Retrospective review of high-frequency ultrasound characteristics of 24 consecutive iris and iridociliary melanomas before and after radiation therapy.
Results The median tumor thickness before radiation therapy was 2.3 mm (range, 1.4-4.3 mm). Nineteen iris melanomas (79%) involved the ciliary body, 18 (75%) involved the iris pigment epithelium, 11 (46%) were club shaped, and 4 (17%) caused disinsertion of the iris root. At a median follow-up of 30 months after plaque brachytherapy, the mean tumor thickness had diminished to 1.2 mm (median, 1.2 mm; range, 0.9-1.9 mm). While all tumors exhibited a reduction in thickness, no tumors showed additional regression after 30 months past treatment. Fourteen tumors (58%) were noted to have increases in internal reflectivity. There was 1 failure of local control (at 6 years), successfully treated by a second application of plaque brachytherapy.
Conclusion High-frequency ultrasonography revealed unique tumor characteristics, quantified tumor size, and demonstrated tumor response to radiation therapy.
Author Affiliations: The New York Eye Cancer Center (Drs Finger and Chin), Department of Ophthalmology, New York University School of Medicine (Drs Finger and Reddy), and The New York Eye and Ear Infirmary (Dr Finger), New York, New York.
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Arch Ophthalmol 2008;126:531-534.
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