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Lucia Scorolli, MD; Mariachiara Morara, MD; Alessandro Meduri, MD; Letizia Bacchi Reggiani, MD; Giuseppe Ferreri, MD; Sergio Z. Scalinci, MD; Renato A. Meduri, MD

Arch Ophthalmol. 2007;125(6):759-764.

Objective  To evaluate the results of treatment with intravitreal triamcinolone acetonide injection in patients with cystoid macular edema secondary to retinitis pigmentosa.

Methods  This prospective, nonrandomized comparative trial included 20 eyes of 20 patients with cystoid macular edema secondary to retinitis pigmentosa (group A) and 20 eyes of 20 control individuals (group B) with the same characteristics who declined treatment. All treated eyes received an intravitreal injection of 0.1 mL of triamcinolone acetonide (4 mg). The total follow-up was 12 months. The main outcome measures were best-corrected visual acuity, central macular thickness measured by optical coherence tomography, and intraocular pressure.

Results  No statistically significant changes were observed in best-corrected visual acuity. Central macular thickness showed statistical differences between the 2 groups. Intraocular pressure showed a statistically significant increase after the first day, at 1 month, and at 3 months in both groups but no significant increase afterward.

Conclusions  Intravitreal triamcinolone administration may be useful for select cases of cystoid macular edema in patients with retinitis pigmentosa but its efficacy seems to be limited over time. Therefore, to obtain a good anatomical result and an improvement of best-corrected visual acuity, further treatment would be necessary after 6 months.

Author Affiliations: Departments of Pathophysiological Optics (Drs Scorolli, Morara, A. Meduri, Scalinci, and R. A. Meduri) and Cardiology (Dr Reggiani), University of Bologna, Bologna, and Department of Ophthalmology, University of Messina, Messina (Dr Ferreri), Italy.

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