This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on ISI (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Viral Infections  • Macular Disorders  • Radiologic Imaging  • Diagnosis  • Infectious Diseases  • Alert me on articles by topic  Social Bookmarking   What's this?

Kristine Enrile Bacsal, MD, DPBO; Soon-Phaik Chee, FRCOphth, FRCS(G); Ching-Li Cheng, FRCOphth, FRCS(Ed); John Vincent Policarpio Flores, MD, MSci

Arch Ophthalmol. 2007;125(4):501-510.

Objective  To describe the clinical spectrum of fundus manifestations and angiographic and optical coherence tomographic features of dengue-associated maculopathy in a large series.

Methods  We reviewed clinical records of patients diagnosed as having dengue maculopathy at the Singapore National Eye Centre between January 1, 2002, and December 31, 2005.

Results  We identified 41 patients with serological evidence of dengue fever who had ocular signs and symptoms not attributable to other diseases within 1 month after onset of symptoms of dengue. Seventy-one eyes had maculopathy. Mean best-corrected visual acuity in the affected eye was 20/40 (range, hand motions to 20/20). Intraretinal hemorrhages were seen in 45% of eyes, usually in association with venous sheathing. Fundus fluorescein angiography demonstrated venular occlusion in 25% or arteriolar and/or venular leakage in 3% and 13%, respectively. Yellow subretinal dots were an unusual finding in 28%. Of these, 50% showed corresponding hypofluorescent spots on indocyanine green angiography. Central or paracentral scotomas were observed in 63%. Twenty-eight patients received steroid treatment. Mean visual acuity showed significant improvement between weeks 2 and 4, with an increasing proportion of eyes achieving a best-corrected visual acuity of 20/40 or better across time.

Conclusion  Fundus fluorescein and indocyanine green angiography, optical coherence tomography, and visual field testing are useful tools in the diagnosis of dengue maculopathy.

Author Affiliations: Department of Ocular Inflammation and Immunology, Singapore National Eye Centre (Drs Bacsal, Chee, and Cheng); Scientific Committee, Singapore Eye Research Institute (Dr Chee); Department of Ophthalmology, National University Hospital (Dr Chee); and Department of Ophthalmology, Yong Loo Lin School of Medicine (Dr Chee), National University of Singapore; and Quality Management Department, Singapore Health Services (Dr Flores).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Emergence of the Severe Syndrome and Mortality Associated with Dengue and Dengue-Like Illness: Historical Records (1890 to 1950) and Their Compatibility with Current Hypotheses on the Shift of Disease Manifestation
Kuno
Clin. Microbiol. Rev. 2009;22:186-201.
ABSTRACT | FULL TEXT