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Loretta Szczotka-Flynn, OD, MS; Sara M. Debanne, PhD; Vinay K. Cheruvu, MSc, MS; Bill Long, BS; Sally Dillehay, OD, EdD; Joseph Barr, OD, MS; Peter Bergenske, OD; Peter Donshik, MD; Glenda Secor, OD; John Yoakum, OD

Arch Ophthalmol. 2007;125(4):488-492.

Objective  To estimate the cumulative probability and risk factors for developing corneal infiltrates after up to 3 years of continuous wear (CW) with lotrafilcon A lenses.

Methods  Patients were fitted with lotrafilcon A lenses and followed up for 3 years. The main outcome variable was the first occurrence of any infiltrative event in either eye. Cox proportional hazards regression was used to model the probability of developing infiltrates as a function of demographic and biomicroscopy findings.

Results  A total of 317 patients participated in this study. The Kaplan-Meier unadjusted cumulative incidence of a corneal infiltrate after CW was 5.7% (95% confidence interval [CI], 3.0%-8.4%) at the end of 1 year, 8.5% (95% CI, 5.2%-11.9%) at the end of 2 years, and 10.3% (95% CI, 6.6%-13.9%) at the end of 3 years. Corneal staining and limbal redness present in the affected eye on a previous visit were significantly associated with the development of an infiltrative event (hazard ratios, 7.23 and 3.18; P<.001 and P = .02, respectively).

Conclusions  Corneal staining and limbal redness may predict the subsequent development of an infiltrative event among CW contact lens patients. The probability of remaining free of any corneal infiltrates at the end of 3 years of CW of contact lenses was 89.7% (95% CI, 86.1%-93.4%).

Author Affiliations: Departments of Ophthalmology (Dr Szczotka-Flynn) and Epidemiology and Biostatistics (Dr Debanne and Mr Cheruvu), Case Western Reserve University School of Medicine, Cleveland, Ohio; CIBA Vision Corporation, Duluth, Ga (Mr Long and Drs Dillehay and Bergenske); College of Optometry, Ohio State University, Columbus (Dr Barr); College of Optometry, Pacific University, Forest Grove, Ore (Dr Bergenske); University of Connecticut Health Center, Farmington (Dr Donshik); and Groat Eyecare Associates, Greensboro, NC (Dr Yoakum). Dr Secor is in private practice in Huntington Beach, Calif.

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