This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (27)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Corneal Disorders  • Optics/ Refraction  • Genetics  • Genetic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Terri L. Young, MD; Ravikanth Metlapally, BS(Opt), PhD; Amanda E. Shay, MS

Arch Ophthalmol. 2007;125(1):38-48.

Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous disorders of the human eye and are ideal for genetic investigation. Moderate to severe refractive errors can predispose individuals to poor visual development, various types of glaucoma, misshapen corneal surfaces, premature cataracts, and loss of retinal integrity, which can lead to detachment. Knowledge of genetic mechanisms involved in refractive error susceptibility may allow treatment to prevent progression or to further examine gene-environment interactions. Early genetic predisposition detection for developing severe refractive errors may be useful for efficient and cost-effective screening program design. This review explores the genetic mechanisms associated with nonsyndromic refractive error development known to date.

Author Affiliations: Departments of Ophthalmology (Drs Young and Metlapally) and Pediatrics (Dr Young) and the Center for Human Genetics (Drs Young and Metlapally and Ms Shay), Duke University Medical Center, Durham, NC.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Replication of the Recessive STBMS1 Locus but with Dominant Inheritance
Rice et al.
IOVS 2009;50:3210-3217.
ABSTRACT | FULL TEXT  

High Myopia Is Not Associated with the SNPs in the TGIF, Lumican, TGFB1, and HGF Genes
Wang et al.
IOVS 2009;50:1546-1551.
ABSTRACT | FULL TEXT  

Evaluation of the X-Linked High-Grade Myopia Locus (MYP1) with Cone Dysfunction and Color Vision Deficiencies
Metlapally et al.
IOVS 2009;50:1552-1558.
ABSTRACT | FULL TEXT  

TGFB1 as a Susceptibility Gene for High Myopia: A Replication Study With New Findings
Zha et al.
Arch Ophthalmol 2009;127:541-548.
ABSTRACT | FULL TEXT  

Absence of Association between COL1A1 Polymorphisms and High Myopia in the Japanese Population
Nakanishi et al.
IOVS 2009;50:544-550.
ABSTRACT | FULL TEXT  

Association of PAX6 Polymorphisms with High Myopia in Han Chinese Nuclear Families
Han et al.
IOVS 2009;50:47-56.
ABSTRACT | FULL TEXT  

Shared Genetic Determinant of Axial Length, Anterior Chamber Depth, and Angle Opening Distance: The Guangzhou Twin Eye Study
He et al.
IOVS 2008;49:4790-4794.
ABSTRACT | FULL TEXT  

Adult-Onset Myopia: The Genes in Myopia (GEM) Twin Study
Dirani et al.
IOVS 2008;49:3324-3327.
ABSTRACT | FULL TEXT  

Myopia and Personality: The Genes in Myopia (GEM) Personality Study
van de Berg et al.
IOVS 2008;49:882-886.
ABSTRACT | FULL TEXT  

The Role of Educational Attainment in Refraction: The Genes in Myopia (GEM) Twin Study
Dirani et al.
IOVS 2008;49:534-538.
ABSTRACT | FULL TEXT  

High Susceptibility to Experimental Myopia in a Mouse Model with a Retinal ON Pathway Defect
Pardue et al.
IOVS 2008;49:706-712.
ABSTRACT | FULL TEXT