• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (75)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Glaucoma  • Genetics  • Genetic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Janey L. Wiggs, MD, PhD

Arch Ophthalmol. 2007;125(1):30-37.

Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive trait, or as a complex multifactorial trait. Genetic approaches have helped define the underlying molecular events responsible for some mendelian forms of the disease and have identified the chromosome locations of genes that are likely to contribute to common complex forms. Future directions include the discovery of new glaucoma genes, determining the clinical phenotypes associated with specific genes and mutations, investigating environmental factors that may contribute to the disease, investigating gene-environment interactions and gene-gene interactions, and developing a mutation database that can be used for diagnostic and prognostic testing.

Author Affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Mass.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Quantitative Proteomics: TGF{beta}2 Signaling in Trabecular Meshwork Cells
Bollinger et al.
IOVS 2011;52:8287-8294.
ABSTRACT | FULL TEXT  

Mitochondria-Targeted Peptide MTP-131 Alleviates Mitochondrial Dysfunction and Oxidative Damage in Human Trabecular Meshwork Cells
Chen et al.
IOVS 2011;52:7027-7037.
ABSTRACT | FULL TEXT  

Application of Advanced Statistics in Ophthalmology
Fan et al.
IOVS 2011;52:6059-6065.
ABSTRACT | FULL TEXT  

Patterns of organization in the development of medical know-how: the case of glaucoma research
Consoli and Ramlogan
Ind Corp Change 2011;0:dtr043v1-dtr043.
ABSTRACT | FULL TEXT  

Genetic Dissection of the Gpnmb Network in the Eye
Lu et al.
IOVS 2011;52:4132-4142.
ABSTRACT | FULL TEXT  

Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area
Khor et al.
Hum Mol Genet 2011;20:1864-1872.
ABSTRACT | FULL TEXT  

Anterior Segment Dysgenesis and Early-Onset Glaucoma in nee Mice with Mutation of Sh3pxd2b
Mao et al.
IOVS 2011;52:2679-2688.
ABSTRACT | FULL TEXT  

Genetic Variants Associated with Optic Nerve Vertical Cup-to-Disc Ratio Are Risk Factors for Primary Open Angle Glaucoma in a US Caucasian Population
Fan et al.
IOVS 2011;52:1788-1792.
ABSTRACT | FULL TEXT  

Processing of Optineurin in Neuronal Cells
Shen et al.
J. Biol. Chem. 2011;286:3618-3629.
ABSTRACT | FULL TEXT  

Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro
Gallenberger et al.
Hum Mol Genet 2011;20:422-435.
ABSTRACT | FULL TEXT  

Variations in NTF4, VAV2, and VAV3 Genes Are Not Involved with Primary Open-Angle and Primary Angle-Closure Glaucomas in an Indian Population
Rao et al.
IOVS 2010;51:4937-4941.
ABSTRACT | FULL TEXT  

Quantitative trait loci associated with murine central corneal thickness
Lively et al.
Physiol. Genomics 2010;42:281-286.
ABSTRACT | FULL TEXT  

OPA1 increases the risk of normal but not high tension glaucoma
Yu-Wai-Man et al.
J. Med. Genet. 2010;47:120-125.
ABSTRACT | FULL TEXT  

Heterozygous Loss-of-Function Variants in CYP1B1 Predispose to Primary Open-Angle Glaucoma
Pasutto et al.
IOVS 2010;51:249-254.
ABSTRACT | FULL TEXT  

Primary Open-Angle Glaucoma: Association with Cholesterol 24S-Hydroxylase (CYP46A1) Gene Polymorphism and Plasma 24-Hydroxycholesterol Levels
Fourgeux et al.
IOVS 2009;50:5712-5717.
ABSTRACT | FULL TEXT  

Gene and Protein Expression Pilot Profiling and Biomarkers in an Experimental Mouse Model of Hypertensive Glaucoma
Walsh et al.
Exp Biol Med 2009;234:918-930.
ABSTRACT | FULL TEXT  

Biobanks and the importance of detailed phenotyping: a case study--the European Glaucoma Society GlaucoGENE project
Founti et al.
Br J Ophthalmol 2009;93:577-581.
ABSTRACT | FULL TEXT  

Inherited mitochondrial optic neuropathies
Yu-Wai-Man et al.
J. Med. Genet. 2009;46:145-158.
ABSTRACT | FULL TEXT  

Effects of Oxidative Stress in Trabecular Meshwork Cells Are Reduced by Prostaglandin Analogues
Yu et al.
IOVS 2008;49:4872-4880.
ABSTRACT | FULL TEXT  

High prevalence of glaucoma in Veli Brgud, Croatia, is caused by a dominantly inherited T377M mutation in the MYOC gene
Zgaga et al.
Br J Ophthalmol 2008;92:1567-1568.
FULL TEXT  

Heritability of Central Corneal Thickness in Chinese: The Guangzhou Twin Eye Study
Zheng et al.
IOVS 2008;49:4303-4307.
ABSTRACT | FULL TEXT  

Angiopoietin-like 7 Secretion Is Induced by Glaucoma Stimuli and Its Concentration Is Elevated in Glaucomatous Aqueous Humor
Kuchtey et al.
IOVS 2008;49:3438-3448.
ABSTRACT | FULL TEXT  

Lack of Association between LOXL1 Variants and Primary Open-Angle Glaucoma in Three Different Populations
Liu et al.
IOVS 2008;49:3465-3468.
ABSTRACT | FULL TEXT  

The LOXL1 Gene Variations Are Not Associated with Primary Open-Angle and Primary Angle-Closure Glaucomas
Chakrabarti et al.
IOVS 2008;49:2343-2347.
ABSTRACT | FULL TEXT  

Heritability of Optic Disc and Cup Measured by the Heidelberg Retinal Tomography in Chinese: The Guangzhou Twin Eye Study
He et al.
IOVS 2008;49:1350-1355.
ABSTRACT | FULL TEXT  

Genomics in the Era of Molecular Ophthalmology: Reflections on the National Ophthalmic Disease Genotyping Network (eyeGENE)
Brooks et al.
Arch Ophthalmol 2008;126:424-425.
FULL TEXT  

The Heritability of Optic Disc Parameters: A Classic Twin Study
Healey et al.
IOVS 2008;49:77-80.
ABSTRACT | FULL TEXT  

Genetic Ophthalmology and the Era of Clinical Care
Sieving and Collins
JAMA 2007;297:733-736.
FULL TEXT